A large amount of the external research work carried out in sonic and ultrasound assisted bioprocessing has used either intense probe or ultrasonic bath based equipment. In fact the cavitation produced with high-power probes can lead to damage of the ultrasonic device where intense cavitation occurs very close to the radiating probe surface. Indeed intense cavitation can destroy cellular activity. For newer and innovative Celbius Sonobioprocessing (SBP) these limitations can be overcome by using the proprietary ultrasonic flow-cell systems manufactured by Sonic Systems Ltd.

Celbius has a range of ultrasound equipment for both laboratory studies and deployment in an industrial environment  and manufacturing trials and can work in collaboration in devising the most appropriate scale-up options by working closely with the Client and appropriate process / ultrasonic engineering partners.

The large scale ultrasonic flow-cell equipment can be ATEX approved for use with flammable solvents or in the manufacture of biofuels such as bioethanol and can be sterilised in readiness for fermentation.

For manufacturing operations it is more usual to configure ultrasonic modules into a recirculation loop. This retro-fit option is useful for fixed or mobile installation to pre-existing fermenters or bioreactors with respect to ease of operation, and reduced capex and opex. The configuration can also be modified easily to incorporate secondary feed streams.